Figure 3
From: Rat and human STINGs profile similarly towards anticancer/antiviral compounds
The lid region in rSTING-cGAMP is distinct from that of the mSTING-agents structures.
(A) Structural comparisons of rSTING-cGAMP (light-blue) with mSTING-DMXAA (red) and mSTING-CMA (yellow). (B) A close-up view of the lid region comparison, color scheme is the same as in (a). (C) A close-up view of residues 230 and 235 involved in interactions. The color scheme is the same as in (a). The cGAMP or agents is colored grey. The left pane shows rSTING-cGAMP and the right pane show mSTING-CMA. The middle pane displays the mSTING-DMXAA. (D) Sequence alignment of the lid region in STING members. The strictly conserved residues are marked by a red background and the conserved residues are shown in red.
