Figure 5 | Scientific Reports

Figure 5

From: CellMethy: Identification of a focal concordantly methylated pattern of CpGs revealed wide differences between normal and cancer tissues

Figure 5

DCMRs of breast cancer from GWBS data.

(A) DCMRs and DMRs. (B) Differential degree of CM fractions and average methylation levels in CMRs. The dotted line represents the cutoff of variance. (C) Overlap between differential CM and methylation regions. H(L)-DCMR represents higher (lower) CM fractions in cancer than normal cells and Hyper(Hypo)-DMR represents higher (lower) average methylation levels in cancer than normal cells. (D) Enrichment analysis of DCMRs that did not show differential methylation levels. Red represents functions enriched in H-DCMRs, green represents functions enriched in L-DCMRs and purple represents functions enriched in both H-DCMRs and L-DCMRs. (E) An example of CM patterns from TERT, ABCB1, GSTP1, IGF2 and BRCA1 that were associated with breast cancer in previous studies. The gray rectangle corresponding to each gene represents the genomic position. Vertical lines represents the locations of CMRs and arrows represents the transcriptional direction of each gene. Purple histograms represents the average methylation level of each CpG in CMR from sequencing reads. Heat map shows methylation state of each CpG in sequencing reads in HCC1954 (left, cancer) and HMEC (right, normal). Red is methylated and gray is unmethylated.

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