Table 1 Characteristics of studies included in the present meta-analysis.
First Author | Year | Number of Patients | Cut-off of IHC | Method of quantification | Hazard ratio (95% CI) | site | Area | Outcome | ||
|---|---|---|---|---|---|---|---|---|---|---|
total | TWIST negative or low | TWIST positive or high | ||||||||
Song | 2006 | 75 | 42 | 33 | ≥ 5% | Percentage of staining | 1.50 (1.05–5.01)* | Nasopharynx | China | (2) (3) (4) (5) (6) (11) (12) |
Ou | 2008 | 50 | 30 | 20 | NA | NA | – | Combined | China | (1) (2) (3) (4) (5) |
Gasparotto | 2011 | 68 | 34 | 34 | NA | NA | 2.18 (1.08–4.41) | Combined | Italy | (5) (11) |
Huang | 2011 | 80 | 27 | 53 | ≥ 5% | Percentage of staining | – | Larynx | China | (1) (2) (4) (5) (6) (7) (12) |
Liang | 2011 | 89 | 49 | 40 | ≥ 5% | Percentage of staining | 3.06 (1.36–6.89)* | Oral | China | (1) (2) (3) (4) (5) (8) (9) (10) (11) |
Lu | 2011 | 66 | 22 | 44 | NA | Percentage of staining | – | Larynx | China | (1) (2) (5) (6) |
Gong | 2012 | 62 | 14 | 48 | ≥ 5% | Percentage of staining | – | Oral | China | (1) (2) (4) (5) (6) (7) |
Wang | 2012 | 60 | 30 | 30 | ≥ 4 | Sum of percentage and intensity | – | Oral | China | (1) (2) (3) (4) (5) |
Wushou | 2012 | 60 | 18 | 42 | ≥ 3 | Sum of percentage and intensity | 4.65 (1.06–20.45) | Oral | China | (1) (2) (3) (4) (5) (6) (7) (8) (9) (11) |
Zheng | 2012 | 69 | 20 | 49 | ≥ 1 | Sum of percentage and intensity | – | Oral | China | (1) (2) (4) (5) (6) (7) |
Fan | 2013 | 114 | 40 | 74 | ≥ 2 | Sum of percentage and intensity | 0.89 (0.52–1.51) | Oral | China | (1) (2) (3) (4) (5) (6) (7) (8) (9) (11) |
Hu | 2013 | 60 | 19 | 41 | ≥ 10% | Percentage of staining | – | Larynx | China | (1) (2) (4) (5) (6) (7) (12) |
da Silva | 2014 | 52 | 30 | 22 | > 2 | Extent of staining | 4.28 (1.03–61.12)* | Oral | Brazil | (3) (4) (5) (10) (11) |
Qian | 2014 | 81 | 34 | 47 | ≥ 30% | Percentage of staining | – | Combined | Germany | (1) (2) (3) (4) (5) (8) (9) |
Zhu | 2014 | 49 | 19 | 30 | 4–12 | Sum of percentage and intensity | – | Larynx | China | (1) (4) (5) (6) (7) |
