Table 1 Frequency of HPV DNA in tissue samples by clinical and histological features.

From: No association between HPV positive breast cancer and expression of human papilloma viral transcripts

 

All samples N (%)

HPV-positive N (%)

HPV-negative N (%)

P-value

Number of samples

90 (100)

14 (16)

76 (84)

 

Age (years)

 <50

35

7 (50)

27 (36)

0.34

 >50

53

7 (50)

47 (61)

 Unknown

2

0 (0)

2 (3)

Diagnosis

 Infiltrating ductal carcinoma

58

9 (64)

49 (64)

0.72

 Infiltrating lobular carcinoma

6

1 (7)

5 (7)

 DCIS

3

0 (0)

3 (4)

 Mixed

11

3 (22)

8 (11)

 Benign

10

1 (7)

9 (12)

 Unknown

2

0 (0)

2 (2)

Grade

 1

7

1 (7)

6 (8)

0.84

 2

33

5 (36)

28 (37)

 3

35

7 (50)

28 (37)

 DCIS

3

0 (0)

3 (4)

 Unknown

2

0 (0)

2 (3)

 Benign

10

1 (7)

9 (12)

Nodes

 Negative

48

9 (64)

39 (51)

0.53

 Positive

30

4 (53)

26 (34)

 Unknown

2

0 (0)

2 (3)

 Benign

10

1 (7)

9 (12)

Estrogen Receptor

 Negative

14

3 (21)

11 (14)

0.62

 Positive

64

10 (72)

53 (70)

 Unknown

2

0 (0)

3 (4)

 Benign

10

1(7)

9 (12)

Progesterone Receptor

 Negative

16

3 (21)

13 (17)

0.80

 Positive

62

10 (72)

52 (68)

 Unknown

2

0 (0)

2 (3)

 Benign

10

1 (7)

9 (12)

HER2-neu

 Negative

63

11 (79)

52 (68)

0.85

 Positive

13

2 (14)

11 (14)

 Unknown

4

0 (0)

4 (5)

 Benign

10

1 (7)

9 (12)

Triple negative status

 Triple Negative

6

1 (7)

5 (7)

1

 Non-triple negative

70

12 (86)

58 (76)

 Unknown

4

0 (0)

4 (5)

 Benign

10

1 (7)

9 (12)

  1. HPV is Human papilloma virus, a positive sample is positive in 1 or greater of 3 MY09/MY11 nested PCR technical repeats. P-Values were obtained by Chi Squared test and a P value of less than 0.05 is statistically significant. Unknown and benign samples were not included in Chi-squared testing for association of HPV DNA with clinic-pathological characteristics.
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