Figure 1

Distribution of histone modification marks for the promoter and enhancer elements at rDNA in human liver cancer cell.

(A) Schematic representation of one human rDNA repeat. ETS: external transcribed spacer; ITS-1/2: internal transcribed spacer-1/2; IGS: intergenic spacer. The coding region, which spans ~0–13.3 kb of the human rDNA repeat, is separated by the non-coding intergenic spacers (IGS). (B) Patterns of histone modifications H3K4me1 at rDNA in human liver cancer cell HepG2 were shown below the human rDNA repeat as determined by the analysis of ChIP-seq data. Enrichment P value was calculated using the negative binomial model. (C) Patterns of histone modifications H3K27ac at rDNA in human liver cancer cell HepG2 were shown below the human rDNA repeat as determined by the analysis of ChIP-seq data. Enrichment P value was calculated using the negative binomial model. (D) Pattern of human liver cancer cell HepG2 Input at rDNA was shown below the human rDNA repeat as determined by the analysis of ChIP-seq data.