Figure 1 | Scientific Reports

Figure 1

From: Increased co-expression of genes harboring the damaging de novo mutations in Chinese schizophrenic patients during prenatal development

Figure 1

Relatedness of 40 genes in the co-expression network in four brain regions at three developmental stages.

We evaluated the co-expression of genes harboring the damaging DNVs in cases and controls using RNA-seq data from the BrainSpan Atlas. Gene pairs were defined as co-expressed if Spearman’s rank correlation coefficient (|R|)> 0.8 for RNA-seq expression levels across different brain areas and a given developmental stage. Networks were created for co-expressed gene pairs as described for Fig. 2. Histograms represent distributions of the numbers of edges in 100,000 simulated networks using genes harboring the damaging DNVs in controls. Dotted lines indicate the numbers of connections (edges) in networks created using genes harboring the damaging DNVs in cases with schizophrenia. The significant enrichment in co-expression of gene mutants in schizophrenia was observed in the frontal cortex and temporal and parietal regions during prenatal development (p < 0.0091 and 0.03 after Bonferroni corrections for multiple comparisons) at prenatal stage. There was no enrichment of co-expression of genes harboring the damaging DNVs at the other stages.

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