Table 1 Generic microarray and qRT-PCR determinations of the mRNA expression levels of deregulated genes involved in TGF-β signal pathway in responding to Akbu-LAAO.

From: Akbu-LAAO exhibits potent anti-tumor activity to HepG2 cells partially through produced H2O2 via TGF-β signal pathway

Gene symbol

fold ratio (Akbu-LAAO-microarray)a

fold ratio (Akbu-LAAO-qRT-PCR)b

fold ratio (Akbu-LAAO + catalase-qRT-PCR)c

CDK6

0.59

0.77

0.89

CCND1

0.62

0.48

0.63

CYR61

0.53

0.36

0.52

P53

1.58

1.30

1.20

BMP2

1.76

2.10

1.67

GADD45A

1.87

2.33

1.56

TOB1

1.61

3.54

2.46

JUN

1.54

3.82

2.79

DUSP1

1.54

3.29

2.65

JUNB

1.60

3.63

2.67

CDKN1A

1.83

4.99

3.78

BTG2

1.78

5.59

4.65

LOX

3.18

10.09

7.23

SMAD9

1.66

10.73

6.25

GDF15

2.33

19.75

14.23

  1. a,bRefer to mRNA level changes of deregulated genes in HepG2 cells in responding to Akbu-LAAO treatment compared with control HepG2 cells; cRefers to the relative mRNA levels of deregulated genes in HepG2 cells in responding to Akbu-LAAO treatment plus catalase compared with control HepG2 cells.
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