Figure 6 | Scientific Reports

Figure 6

From: Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety

Figure 6

Incidence of ventricular tachyarrhythmias after β-adrenergic stimulation with isoproterenol (ISOP, 0.02 mg/kg) in HAB (n = 8).

The injection of ISOP was preceded by inhibition of FAAH activity with URB694 (URB, 0.3 mg/kg) or vehicle (VEH) administration. URB was administered in the presence of CB1 or CB2 receptor blockade with rimonabant (RIM, 2 mg/kg) or AM630 (2 mg/kg), respectively, or after VEH injection. Data are reported as means ± SEM of a 30-min time period. VEH+VEH+ISOP group served as control for VEH+URB+ISOP group. VEH+URB+ISOP group served as control for RIM+URB+ISOP and AM630+URB+ISOP group. Significant differences (p < 0.05): avs. VEH+VEH+ISOP group; bvs. VEH+URB+ISOP group.

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