Table 1 Heart rate, heart rate variability parameters and incidence of ventricular arrhythmias in HAB, NAB and LAB rats (n = 9 per group) in baseline conditions and in response to (i) vehicle (VEH) + isoproterenol (ISOP, 0.02 mg/kg) injections (left columns) and (ii) URB694 (URB, 0.3 mg/kg) + ISOP injections (right columns).

From: Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety

Heart rate (bpm)

HAB

NAB

LAB

Heart rate (bpm)

HAB

NAB

LAB

Basal (30 min)

352 ± 11

364 ± 6

364 ± 13

Basal (30 min)

355 ± 7

383 ± 12

363 ± 17

VEH (30 min)

359 ± 9ab

401 ± 9

403 ± 13

URB (30 min)

348 ± 6ab

404 ± 11

398 ± 11

ISOP (30 min)

476 ± 9

477 ± 8

494 ± 9

ISOP (30 min)

467 ± 11

484 ± 7

477 ± 19

RMSSD (ms)

HAB

NAB

LAB

RMSSD (ms)

HAB

NAB

LAB

Basal (30 min)

4.0 ± 0.4

4.0 ± 0.3

4.5 ± 0.6

Basal (30 min)

4.0 ± 0.4

3.4 ± 0.3

4.2 ± 0.4

VEH (30 min)

3.9 ± 0.3

3.9 ± 0.3

4.1 ± 0.4

URB (30 min)

3.8 ± 0.4

3.2 ± 0.4

3.9 ± 0.4

ISOP (30 min)

1.8 ± 0.2

2.6 ± 0.2

2.3 ± 0.2

ISOP (30 min)

2.0 ± 0.2

2.3 ± 0.5

2.0 ± 0.4

HF (ms2)

HAB

NAB

LAB

HF (ms2)

HAB

NAB

LAB

Basal (30 min)

5.9 ± 1.0

5.3 ± 0.8

7.7 ± 2.4

Basal (30 min)

5.7 ± 1.1

4.3 ± 0.8

6.5 ± 1.4

VEH (30 min)

5.2 ± 0.7

5.3 ± 0.7

6.8 ± 0.9

URB (30 min)

5.5 ± 1.0

3.8 ± 1.1

5.8 ± 1.5

ISOP (30 min)

1.5 ± 0.3

2.8 ± 0.6

2.3 ± 0.3

ISOP (30 min)

2.0 ± 0.5

2.7 ± 1.2

2.2 ± 0.7

LF/HF

HAB

NAB

LAB

LF/HF

HAB

NAB

LAB

Basal (30 min)

0.8 ± 0.1

0.6 ± 0.1

0.6 ± 0.1

Basal (30 min)

0.8 ± 0.1

0.7 ± 0.1

0.8 ± 0.1

VEH (30 min)

0.9 ± 0.1

0.7 ± 0.1

0.8 ± 0.1

URB (30 min)

0.8 ± 0.1

0.9 ± 0.1

1.0 ± 0.1

ISOP (30 min)

0.7 ± 0.1

0.6 ± 0.1

0.7 ± 0.1

ISOP (30 min)

0.7 ± 0.1

0.6 ± 0.1

0.8 ± 0.1

Arrhythmias (n)

HAB

NAB

LAB

Arrhythmias (n)

HAB

NAB

LAB

Basal (30 min)

0.2 ± 0.2

0.1 ± 0.1

0.0 ± 0.0

Basal (30 min)

0.0 ± 0.0

0.0 ± 0.0

0.0 ± 0.0

VEH (30 min)

2.3 ± 2.2

0.4 ± 0.2

0.1 ± 0.1

URB (30 min)

0.3 ± 0.2

0.4 ± 0.3

0.0 ± 0.0

ISOP (30 min)

41.7 ± 12.3ab

11.8 ± 2.5

12.3 ± 2.6

ISOP (30 min)

14.1 ± 4.2*

8.4 ± 2.2

7.3 ± 3.7

  1. Data are reported as means ± SEM of the indicated time periods. Significant differences (p < 0.05): avs. NAB value, bvs. LAB value, *vs. respective control value.
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