Table 3 Heart rate, heart rate variability parameters and incidence of ventricular arrhythmias in HAB rats (n = 8) in baseline conditions and in response to the following sequences of injections: (i) vehicle (VEH) + VEH + isoproterenol (ISOP, 0.02 mg/kg), (ii) VEH + URB694 (URB, 0.3 mg/kg) + ISOP, (iii) rimonabant (RIM, 2 mg/kg) + URB + ISOP and (iv) AM630 (2 mg/kg) + URB + ISOP.

From: Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety

Heart rate (bpm)

VEH + VEH + ISOP

VEH + URB + ISOP

RIM + URB + ISOP

AM630 + URB + ISOP

Basal (30 min)

343 ± 9

349 ± 7

358 ± 8

353 ± 7

Injection 1 (30 min)

356 ± 10

350 ± 5

404 ± 11b

359 ± 8

Injection 2 (30 min)

353 ± 6

348 ± 10

392 ± 10b

346 ± 9

ISOP (30 min)

462 ± 9

417 ± 11a

462 ± 7b

438 ± 8

RMSSD (ms)

VEH + VEH + ISOP

VEH + URB + ISOP

RIM + URB + ISOP

AM630 + URB + ISOP

Basal (30 min)

2.8 ± 0.2

2.9 ± 0.3

2.8 ± 0.3

3.1 ± 0.3

Injection 1 (30 min)

2.7 ± 0.2

3.0 ± 0.3

2.8 ± 0.3

2.8 ± 0.3

Injection 2 (30 min)

2.7 ± 0.2

3.0 ± 0.4

2.9 ± 0.3

2.9 ± 0.3

ISOP (30 min)

1.6 ± 0.2

2.5 ± 0.2a

1.6 ± 0.2b

1.6 ± 0.2

HF (ms2)

VEH + VEH + ISOP

VEH + URB + ISOP

RIM + URB + ISOP

AM630 + URB + ISOP

Basal (30 min)

2.8 ± 0.4

2.9 ± 0.7

2.8 ± 0.6

3.5 ± 0.7

Injection 1 (30 min)

2.5 ± 0.4

3.2 ± 0.5

2.5 ± 0.5

3.1 ± 0.6

Injection 2 (30 min)

2.3 ± 0.3

3.3 ± 0.8

3.0 ± 0.6

2.8 ± 0.5

ISOP (30 min)

1.2 ± 0.2

2.5 ± 0.4a

1.2 ± 0.3b

1.7 ± 0.2

LF/HF

VEH + VEH + ISOP

VEH + URB + ISOP

RIM + URB + ISOP

AM630 + URB + ISOP

Basal (30 min)

0.7 ± 0.1

0.8 ± 0.1

0.8 ± 0.1

0.8 ± 0.1

Injection 1 (30 min)

1.0 ± 0.1

0.8 ± 0.1

1.2 ± 0.1b

1.0 ± 0.1

Injection 2 (30 min)

1.0 ± 0.1

0.9 ± 0.1

1.1 ± 0.1

0.9 ± 0.1

ISOP (30 min)

0.7 ± 0.1

0.8 ± 0.1

0.6 ± 0.1

0.8 ± 0.1

Arrhythmias (n)

VEH + VEH + ISOP

VEH + URB + ISOP

RIM + URB + ISOP

AM630 + URB + ISOP

Basal (30 min)

0.3 ± 0.2

0.3 ± 0.2

0.4 ± 0.2

0.4 ± 0.3

Injection 1 (30 min)

0.4 ± 0.2

0.3 ± 0.3

2.9 ± 0.8b

0.6 ± 0.3

Injection 2 (30 min)

0.3 ± 0.3

0.3 ± 0.2

2.4 ± 1.2

0.3 ± 0.3

ISOP (30 min)

49.5 ± 10.2

25.3 ± 7.3a

43.6 ± 10.5b

24.1 ± 3.9

  1. Data are reported as means ± SEM of the indicated time periods. VEH + VEH + ISOP group served as control for VEH + URB + ISOP group. VEH + URB + ISOP group served as control for RIM + URB + ISOP and AM630 + URB + ISOP group. Significant differences (p < 0.05): avs. VEH + VEH + ISOP group; bvs. VEH + URB + ISOP group.
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