Figure 4

TLR2 deficiency promotes the growth of plasmodium yoelii.

(A–C), WT, MyD88^−/−, TLR4^−/− and TLR2^−/− mice (n = 6) were challenged intravenously with sporozoites. 42 h later, liver parasite burden (A) was detected by quantitative PCR, parasitemia was examined by Giemsa staining (B) and survival rate (C) was recorded. D–F, WT and TLR2^−/− mice (n = 6) were challenged through the bite of infected mosquitoes. 42 h later, liver parasite burden (D) was detected by quantitative PCR and parasitemia (E) and survival rate (F) were recorded. G, WT and TLR2^−/− mice (n = 6) were injected intraperitoneally with the parasitized RBC and the parasitemia was determined every two days. All the experiments were repeated for three times and all the data were presented as the mean ± SD, *p < 0.05.