Figure 2 | Scientific Reports

Figure 2

From: The effect of androgens on ovarian follicle maturation: Dihydrotestosterone suppress FSH-stimulated granulosa cell proliferation by upregulating PPARγ-dependent PTEN expression.

Figure 2

Effects of DHT and DHEA on estrous cycles and follicular maturation.

The data are shown as means ± SD. (A) The interestrus intervals of the rats were determined by vaginal smears. The interestrus interval of the DHT group was significantly higher than that of the other two groups. Number of rats = 16, 14 and 14 in the DHT, DHEA and placebo groups, respectively. (B) At the end of the study, the rat ovaries were fixed for histology. Representative HE staining is shown (40×), bar = 300 μm. (C) Quantitative results of total antral follicle count, including small and large antral follicles, among the 3 groups. The large follicle count of the DHT group was significantly higher than that of the other 2 groups. (D) Quantitative results of the mature and ovulated follicle count, including the Graafian follicles and corpus lutea, among the 3 groups. The mature and ovulated follicle count of the DHT group was significantly lower than that of the other 2 groups. For the antral follicle measurements in (C,D), number of rats = 8, 7 and 8 in the DHT, DHEA and placebo groups, respectively. Between-group comparisons are indicated. *P < 0.05.

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