Table 2 Circulating hormonal and metabolic profiles of placebo-, DHT- and DHEA-treated rats.

From: The effect of androgens on ovarian follicle maturation: Dihydrotestosterone suppress FSH-stimulated granulosa cell proliferation by upregulating PPARγ-dependent PTEN expression.

 

Placebo rats

DHT rats

DHEA rats

FSH (IU/L)

2.64 ± 0.63

3.25 ± 0.21

3.30 ± 0.28

LH (IU/L)

0.26 ± 0.06b,c

0.51 ± 0.04ab

0.02 ± 0.01a,c

E2 (pg/mL)

13.82 ± 2.37

6.55 ± 1.67

26.07 ± 12.79

P4 (ng/mL)

25.82 ± 3.95

13.20 ± 3.27

25.78 ± 6.10

Testosterone (ng/mL)

0.11 ± 0.02b

0.06 ± 0.02b

0.17 ± 0.02a,c

DHEAS (μg/dL)

2.08 ± 0.20b

1.13 ± 0.23b

3.20 ± 0.56a,c

Androstenedione

0.94 ± 0.71c

0.47 ± 0.23a,b

0.98 ± 0.10c

Glucose (mg/dL)

109.44 ± 8.23

114.37 ± 5.92

138.65 ± 21.17

Insulin (μg/L)

0.25 ± 0.04

0.48 ± 0.16

0.21 ± 0.04

Total cholesterol (mg/dL)

51.25 ± 2.93b,c

36.05 ± 3.51a,b

63.41 ± 4.07a,c

HDL-C (mg/dL)

22.67 ± 1.11b,c

16.43 ± 1.13a,b

27.43 ± 1.41a,c

LDL-C (mg/dL)

5.25 ± 0.52

5.11 ± 0.27

4.53 ± 0.37

Triglycerides (mg/dL)

54.12 ± 3.24b

61.21 ± 5.33b

83.53 ± 6.55a,c

AST (U/L)

142.75 ± 10.58

289.74 ± 65.11

226.41 ± 47.04

ALT (U/L)

40.37 ± 2.27c

61.68 ± 7.61a

47.00 ± 5.28

Adiponectin (μg/mL)

10.63 ± 0.91b

9.09 ± 0.60

8.26 ± 0.70a

  1. The data are expressed as the mean ± SEM (n = 16–19 rats per group; FSH, LH, DHEAS and androstenedione, n = 8–10 rats per group).
  2. aP <0.05 vs. placebo group
  3. bP < 0.05 vs. DHEA group
  4. cP < 0.05 vs. DHT group.
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