Figure 4 | Scientific Reports

Figure 4

From: Chronic Metabolic Acidosis Activates Renal Tubular Sodium Chloride Cotransporter through Angiotension II-dependent WNK4-SPAK Phosphorylation Pathway

Figure 4

Effect of acidosis on expression and phosphorylation of NCC in WNK4−/− mice.

WNK4 knockout mice had reduced levels of total NCC and p-NCC in kidney tissues. Acidosis increased the expression of total and p-NCC in WNK4+/+ mice, but not in WNK4−/− mice (6 mice/group, 3 separate gels). *p < 0.05 vs. WNK4+/+ mice; #p < 0.05 vs. WNK4+/+ mice with acidosis. The blots and gels were cropped and the full-length blots/gels are presented in Supplementary Fig. S5.

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