Figure 4 | Scientific Reports

Figure 4

From: Identification of potential mitochondrial CLPXP protease interactors and substrates suggests its central role in energy metabolism

Figure 4

The different roles of mitochondrial CLPXP.

The proteolytic component CLPP degrades misfolded mitochondrial proteins in C. elegans to initiate UPRmt stress signalling, which leads to the induction of nuclear-encoded mitochondrial protective genes15. Our study identifies specific proteins and pathways that are likely targets of CLPXP, suggesting a dedicated role of this protease in regulation and maintenance of mitochondrial energy metabolism. The observation that CLPP-knockdown in cancer cells impairs oxidative phosphorylation is in support of this emerging view17. Furthermore, several chaperones and components of other mitochondrial pathways, e.g. those controlling translation, redox homeostasis and amino acid biosynthesis, were found as additional potential targets or interactors of CLPXP.

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