Figure 6
From: A white spot syndrome virus microRNA promotes the virus infection by targeting the host STAT
The pathway mediated by viral miRNA in virus infection.
(A) Effects of viral miRNA silencing on the expressions of TEP1 and TEP2. WSSV-miR-22-mimic and WSSV were co-injected into shrimp. At different time after injection, the mRNA levels of TEP1 and TEP2 were quantified by quantitative real-time PCR. (B) The relationship between shrimp STAT and TEPs. The WSSV-infected shrimp were injected with STAT-siRNA to silence the expression of STAT gene, followed by the quantification of TEP1 or TEP2 mRNA using quantitative real-time PCR. (C) The relationship between shrimp JAK and TEPs. WSSV and JAK-siRNA were co-injected into shrimp. At different time post-infection, the mRNA levels of TEP1 and TEP2 were detected with quantitative real-time PCR. (D) Mode for the viral miRNA-mediated pathway in virus infection in vivo. Statistically significant differences between treatments were indicated by asterisks (**p < 0.01).
