Figure 4 | Scientific Reports

Figure 4

From: Cytokine levels contribute to the pathogenesis of minimal hepatic encephalopathy in patients with hepatocellular carcinoma via STAT3 activation

Figure 4

Cytokines-induced neural apoptosis in HCC is STAT3-dependent.

Human neuron cells were left untreated (control) or treated with S3I alone or in combination different cytokine (IL-1β, IL-6, IL-17a, IFNγ or IFNλ3), respectively for 72 hrs. The levels of activated STAT3 were measured by flow cytometry (A). The levels of induced apoptosis were measured by TUNEL assay (B) and Caspase3 activation (C). Data represent a minimum of three independent experiments. Asterisks denote p < 0.05 in comparison to untreated samples.

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