Table 1 The association between IFNAR1 gene SNPs and EV71 HFMD susceptibility.

From: A functional polymorphism in IFNAR1 gene is associated with susceptibility and severity of HFMD with EV71 infection

SNP ID

Genotype

HD

EV71

Multiplicative

Additive

Dominant

Recessive

No (%)

No (%)

P Value

OR (95% CI)

P Value

OR (95% CI)

P Value

OR (95% CI)

P Value

OR (95% CI)

rs2843710

CC

251 (43.8)

442 (37.0)

0.0001

1.34(1.15–1.55)

<0.0001

0.49(0.35–0.69)

0.0002

0.54(0.39–0.74)

0.005

1.33(1.09–1.63)

 

CG

269 (46.9)

565 (47.2)

  

0.002

0.58(0.42-0.82)

    
 

GG

53 (9.3)

189 (15.8)

  

Ref.

Ref.

    

rs1787572

GG

196 (34.2)

466 (39.0)

0.2019

0.91(0.79–1.05)

0.4725

0.89(0.66–1.21)

0.8764

1.02(0.78–1.35)

0.0530

0.81(0.66–1.00)

 

GT

290 (50.6)

545 (45.6)

  

0.4067

1.13(0.85–1.52)

    
 

TT

87 (15.2)

185 (15.4)

  

Ref.

Ref.

    

rs113181057

TT

573(100.0)

1196(100.0)

—

—

—

—

—

—

—

—

 

TC

0 (0.0)

0 (0.0)

  

—

—

    
 

CC

0 (0.0)

0 (0.0)

  

Ref.

Ref.

    

rs1012334

AA

195 (34.0)

410 (34.3)

0.2813

0.92(0.80–1.07)

0.1516

0.81(0.60–1.08)

0.0607

0.78(0.60–1.01)

0.9175

0.99(0.80–1.22)

 

AT

268 (46.8)

599 (50.1)

  

0.0517

0.76(0.58–1.00)

    
 

TT

110 (19.2)

187 (15.6)

  

Ref.

Ref.

    
  1. Note: Hardy-Weinberg equilibrium P values of 4 SNPs (in the order of rs2843710, rs17875752, rs113181057, rs1012334) were 0.11, 0.23, 0.00 and 0.30 in HD and were 0.71, 0.22, 0.00 and 0.19 in EV71. Abbreviations: HD, healthy donors; EV71, EV71 HFMD; CI, confidence interval; OR, odds ratio.
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