Figure 1
From: Col4a1 mutations cause progressive retinal neovascular defects and retinopathy
Col4a1+/Δex41 mice revealed variable retinal phenotypes when imaged in vivo by funduscopy, some of which associated with hyperfluorescent signals in fluorescein angiography (FA).
Funduscopy (a) and FA (b) of Col4a1+/+ control mice were unremarkable. In contrast, Col4a1+/Δex41 mice (c–l), showed variable retinal phenotypes by funduscopy and a ramified and tortuous retinal vasculature by FA. One can distinguish between two types of lesions, larger yellow-white intraretinal lesions with irregular borders associated with hyperfluorescent signals in FA (c,d), as well as smaller disciform lesions with well-defined borders not associated with acute dye leakage (e,f). Occasionally we also found active sites of hemorrhage in Col4a1+/Δex41 mice (g,h). Longitudinal follow-up over two months from P60 to P120 of two lesions in the same eye of a Col4a1+/Δex41 mouse revealed that large hyperfluorescent lesions either persisted and grew in size (i–l, dotted area) or regressed into smaller, disciform lesions that no longer hyper-fluoresced on FA (i–l, arrow). Ages: (a–f), 4 months; (e,f) 6 weeks; (g,h), 12 months.
