Figure 2
From: Col4a1 mutations cause progressive retinal neovascular defects and retinopathy
Col4a1+/Δex41 mice show numerous retinal abnormalities at different ages in light micrographs.
Histological analysis of H&E stained retinal sections of Col4a1+/+ and Col4a1+/Δex41 mice at embryonic day (E) 16.5 (a,b), 1.5 months (c,d), 5 months (e,f) and 24 months (g,h). At younger ages, Col4a1+/Δex41 eyes predominantly show vitreal (asterisk in b) and subretinal hemorrhages (d). At older ages, Col4a1+/Δex41 eyes revealed the presence of abnormal blood vessels (arrows in h), fibrosis and retinal restructuring (f,h). The histological findings were consistent with in vivo imaging studies. GCL, ganglion cell layer; IPL, inner plexiform layer; INL, inner nuclear layer; OPL, outer plexiform layer; ONL, outer nuclear layer; OS, outer segments; RPE, retinal pigment epithelium. Bar: 100 μm.
