Figure 3
From: Col4a1 mutations cause progressive retinal neovascular defects and retinopathy
Ultra-structural analyses revealed age-dependent accumulation of amorphous deposits at the RPE-photoreceptor complex in Col4a1+/Δex41 mice.
Electron micrographs of the photoreceptor/RPE/Bruch’s membrane complex revealed thickening of Bruch’s membrane compared to age-matched Col4a1+/+ littermate controls (a,b) in retinas from 1-month old Col4a1+/Δex41 mice (c,e). At 2 years of age, extensive accumulations of amorphous material were observed in Col4a1+/Δex41 mice (d,f, arrow heads) compared to Col4a1+/+ mice (b). (e,f) are higher magnifications of the insets in (c,d), respectively. Bars in (a–c,e): 2 μm; bar in (e): 100 nm; bar in (f): 50 nm.
