Figure 4
The time-dependent deterioration of both scotopic (A) and photopic ERG (B) ERGs of the MNU treated mouse. The mean amplitude of the scotopic b- wave decreased significantly in the MNU treated eyes at P1, while the mean amplitude of the photopic b- wave was unaffected. Subsequently at P3, the mean amplitudes of both the scotopic and photopic b- wave decreased significantly in the MNU treated eyes compared with the controls. At P5, the reduction in the mean amplitudes of photopic and scotopic b-wave progressed with time. Furthermore at P7, the scotopic b-waves were undetectable in the MNU treated eyes, whereas a minimum of the b-wave amplitudes were relatively retained in the photopic ERG forms of these eyes. These residual photopic b-waves eventually disappeared by P9 (ANOVA analysis followed by post-hoc test, n = 12; *P < 0.05, **P < 0.01 for differences between groups).
