Figure 1 | Scientific Reports

Figure 1

From: Developmental genes significantly afflicted by aberrant promoter methylation and somatic mutation predict overall survival of late-stage colorectal cancer

Figure 1

Schematic of methodology applied in this study.

Step I: Integration of genomic, DNA methylomic and transcriptomic data to identify three candidate gene groups; Step II: Identification of gene ontology (GO) function term and corresponding gene groups of interest based on GO enrichment analysis; Step III: Identification of genes within the identified functional groups significantly afflicted by genetic or epigenetic dysregulation, by applying random walk with restart algorithm in the merged network. Step IV: Survival analysis of identified significant genes to evaluate their prognostic value.

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