Figure 7
From: RPS23RG1 reduces Aβ oligomer-induced synaptic and cognitive deficits
Rps23rg1 overexpression reduces oAβ-induced synaptic toxicity in mice.
(A) Golgi staining showing dendritic spines in the hippocampus of wild type (WT) or Rps23rg1 transgenic (Tg) mice injected with oAβs or vehicle. Scale bar, 5 μm. (B) Quantification of spine densities in (A). (C) Rps23rg1 overexpression prevented oAβ-induced PKA inactivation. PKA activity was determined in Rps23rg1 Tg and WT mice injected with oAβs or vehicle in the hippocampus. (D–L) Representative gel images (D) and summary bar graphs showing expression of p-GSK-3 (E), total GSK-3 (F), p-CREB (G), total CREB (H), PHF-1 p-tau (I), total tau (J), synaptophysin (SYP, K) and PSD-95 (L). Values were mean ± SEM (n = 4, n.s., not significant, *p < 0.05, **p < 0.01 one-way ANOVA with Dunnett’s multiple comparisons).
