Figure 8
From: RPS23RG1 reduces Aβ oligomer-induced synaptic and cognitive deficits
Rps23rg1overexpression alleviates oAβ-induced LTP suppression in the hippocampal CA1 region.
(A,B) Induction of LTP in CA1 was significantly attenuated in wild type (WT) mouse CA1, but not in Rps23rg1 transgenic (Tg) mouse CA1, following oAβ injection, when compared to WT mice injected with vehicle. In panel (B), horizontal line = 10 msec and vertical line = 0.2 mV. LTP was recorded on 4, 5, 7 slices from 3 WT/V, 4 WT/Aβ and 6 Tg/Aβ mice, respectively. Values were mean ± SEM (*p < 0.05 by two-way ANOVA with Dunnett’s multiple comparisons).
