Figure 2
From: Altered brain energetics induces mitochondrial fission arrest in Alzheimer’s Disease
3D EM reconstruction of mitochondria in CA1 hippocampi of NTG and APP/PS1 mice.
TEM images from ~28 serial sections 0.09 μm thick were stacked, aligned and reconstructed using 3D reconstruction software in NTG (a) and APP/PS1 (b,c) mice 40 weeks of age (n = 3–5 per each group, all females). Scale bars, 2 μm. (d) Blind morphometric analysis of randomly selected EM of MOAS in CA1 brain region of FAD mice compared to NTG age-matched control at different ages (n = 3–9 mice per group, all females). Ten random sections with ~100 mitochondria were taken into analysis for each brain tissue. Data represent average ± SEM. NTG mice in the graph include NTG1 and NTG2 that did not have MOAS at 40 or 60 weeks of age.
