Figure 3
From: Altered brain energetics induces mitochondrial fission arrest in Alzheimer’s Disease
MOAS phenotype in hippocampi and entorhinal cortices of AD patients.
The hippocampi, entorhinal cortices and cerebella were collected and fixed 6 – 24 hrs postmortem. (a) Low magnification representative survey image of hippocampus from an AD patient illustrating the overall degree of tissue preservation. The box contains teardrop shaped mitochondrion with membrane extension. (b) Representative EM micrograph of mitochondrial profiles in cerebellum from control individual. (c,d) Representative micrographs of teardrop shaped mitochondria with tubular membrane extensions observed in hippocampi from individuals diagnosed with AD (c,d). (e,f) Serial sections demonstrating MOAS phenotype in the hippocampus of an AD patient. Scale bars, 0.5 μm. Demographic data is presented in Supplementary Table S1.
