Table 2 Top 10 most overrepresented KEGG pathways for the DEGs.
Pathway id | Pathway name | Count | P-value | Adjusted |
|---|---|---|---|---|
p-value | ||||
Up-regulated DEGs | ||||
path:04662 | B cell receptor signaling pathway | 14 | 0 | 0 |
path:04650 | Natural killer cell mediated cytotoxicity | 14 | 8.88178E-16 | 6.94556E-13 |
path:04664 | Fc epsilon RI signaling pathway | 11 | 2.87992E-13 | 9.65184E-11 |
path:04062 | Chemokine signaling pathway | 18 | 1.55209E-12 | 3.64121E-10 |
path:04380 | Osteoclast differentiation | 12 | 2.35412E-12 | 4.6023E-10 |
path:04666 | Fc gamma R-mediated phagocytosis | 10 | 5.50975E-11 | 8.07867E-09 |
path:04810 | Regulation of actin cytoskeleton | 12 | 1.0021E-09 | 1.17546E-07 |
path:05144 | Malaria | 6 | 1.90164E-08 | 1.71586E-06 |
path:04670 | Leukocyte transendothelial migration | 7 | 2.39578E-08 | 2.00732E-06 |
path:04610 | Complement and coagulation cascades | 8 | 7.67467E-08 | 5.00133E-06 |
Down-regulated DEGs | ||||
path:04350 | TGF-beta signaling pathway | 4 | 0.0000639 | 0.075854499 |
path:04713 | Circadian entrainment | 5 | 0.000112157 | 0.075854499 |
path:04728 | Dopaminergic synapse | 6 | 0.000272488 | 0.109483429 |
path:04020 | Calcium signaling pathway | 8 | 0.000326677 | 0.109483429 |
path:04724 | Glutamatergic synapse | 6 | 0.00056299 | 0.146752804 |
path:04540 | Gap junction | 4 | 0.000822902 | 0.154822692 |
path:04723 | Retrograde endocannabinoid signaling | 3 | 0.000923945 | 0.154822692 |
path:04270 | Vascular smooth muscle contraction | 4 | 0.000934306 | 0.154822692 |
path:04730 | Long-term depression | 4 | 0.001055909 | 0.154822692 |
path:00380 | Tryptophan metabolism | 3 | 0.001142806 | 0.154862355 |
