Table 1 In vivo anti cancer activity of 3-AWA.

From: Dual modulation of Ras-Mnk and PI3K-AKT-mTOR pathways: A Novel c-FLIP inhibitory mechanism of 3-AWA mediated translational attenuation through dephosphorylation of eIF4E

Treatment groups

Avg. body weights (g) of animals on days

12th day

1st

5th

9th

Av. body weights (g)

Avg. Volume of ascitic fluid (ml)

Av. weight of ascitic fluid (g)

Av. no. of tumor cells (107)

% tumor cell growth

% tumor growth inhibition

Mortality

3-AWA (10 mg/kg i.p.)

21.52

22.32

21.45

21.76

3.11 ± .88

2.93 ± .87

37.8 ± 2.29*

29.5

70.5

0/8

5-FU (22 mg/kg i.p.)

22.85

21.22

20.34

21.47

1.43 ± 0.21

1.13 ± 0.15

31.5 ± 0.78**

24.6

87.4

0/8

Normal saline (0.2 ml i.p.)

24.22

22.16

23.13

23.17

9.76 ± 0.30

9.73 ± 0.69

128.42 ± 9.87

100

—

0/8

  1. Values are mean ± S.E. (n = 7, 10 for control). *P < 0.05, **P < 0.01 versus normal saline control. Comparisons were made between the control and treated groups using the Student’s t-test.
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