Figure 2
From: Fatigue-induced Orosomucoid 1 Acts on C-C Chemokine Receptor Type 5 to Enhance Muscle Endurance
ORM1 is an endogenous anti-fatigue protein.
(a,b) ORM1 expression in muscle, liver tissues (a), or serum (b) in control and forced swimming mice (n = 6). (c) Effect of ORM1 on mice swimming ability. Swimming tests were carried out 30 minutes after the mice were intravenously injected with exogenous ORM1 or vehicle (n = 7 per group). (d) Muscle glycogen contents 30 min after treatment with vehicle or 200 mg/kg ORM1 in mice (n = 7 per group). (e) Swimming times of wild-type mice (WT), ORM1 knockout mice (KO) and ORM1 knockout mice injected with 200 mg/kg of ORM1 (n = 6 per group). (f) Representative records of electrically evoked contractions of soleus muscle isolated from C57/BL mice treated as mentioned in (e) (n = 6). All data are expressed as the mean ± s.d. *P < 0.05, **P < 0.01 by Dunnett’s t test.
