Figure 2
From: Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMP-STING-IRF3 Mediated Innate Immune Response
cGAMP Induces Apoptosis of Tumors.
(A) TUNEL assay of tumor tissues using the “In Suit Cell Death Detection Kit, Fluorescein” (Roche, Germany). (B) Hematoxylin-Eosin staining assay of tumor tissues in control group and cGAMP-treated tumor-bearing mice (20 mg/kg). The nuclei and their fragments are blue-violet and the cytoplasm is pink-red. Scale bar = 100 μm. DAPI is 4,6-diamidino-2-phenylindole and TUNEL assay is terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling assay.
