Figure 3
From: Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMP-STING-IRF3 Mediated Innate Immune Response
cGAMP Stimulates Cytokines Production.
Colon 26 tumor-bearing mice were treated from day 0 to day 20 with 20 mg/kg cGAMP. (A) Cytokines production of IFN-β, IFN-γ were measured by ELISA in serum at the 20th day and (B) Tumor tissues from tumor-bearing mice were detected by quantitative SYBR Green real-time PCR. Representative data are shown from three experiments conducted with 10 mice per group. Data are represented as mean ± SEM, *p < 0.05 and **p < 0.01(Student’s t test).
