Figure 6
From: Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMP-STING-IRF3 Mediated Innate Immune Response
STING Is Essential for the Antitumor Activity of cGAMP.
WT and STING−/− (Tmem173−/−) mice were inoculated and treated with cGAMP (20 mg/kg) for twenty days. (A) Mean tumor volumes, (B) Tumor weights, (C) Tumor inhibition rate, (D) Survial of tumor mice were showed. Representative data are shown from three experiments conducted with 10 mice per group. Data are represented as mean ± SEM, *p < 0.05 and **p < 0.01 (Student’s t test).
