Table 4 Validation of NA inhibition ability for small molecules.

From: Computational screen and experimental validation of anti-influenza effects of quercetin and chlorogenic acid from traditional Chinese medicine

 

Concentration (μg/ml)

Mean CPE ± S.D.

ER(%)

Mean fluorescence intensity (A.U ± S.D.)

Chlorogenic acid

50

2.00 ± 0.00***

52.7***

2.25 ± 0.39***

25

2.25 ± 0.50***

43.8***

3.31 ± 0.25***

12.5

3.00 ± 0.50**

25.6**

4.11 ± 0.32***

6.25

3.33 ± 0.50*

17.8*

4.43 ± 0.38***

3.125

3.67 ± 0.58

10.2

4.75 ± 0.45**

1.563

4.00 ± 0.00

5.3

5.67 ± 0.57

Quercetin

50

1.67 ± 0.00***

59.3***

1.74 ± 0.16***

25

2.00 ± 0.00***

50.6***

2.67 ± 0.20***

12.5

2.33 ± 0.58***

41.5**

3.50 ± 0.26***

6.25

3.00 ± 0.00**

26.3**

4.34 ± 0.31***

3.125

3.33 ± 0.58*

19.4*

4.63 ± 0.41***

1.563

3.33 ± 0.58*

17.7*

5.48 ± 0.52*

Zanamvir

50

0.00 ± 0.00***

87.3***

1.24 ± 0.11***

25

0.00 ± 0.00***

84.1***

1.73 ± 0.15***

12.5

0.67 ± 0.58***

79.6***

2.20 ± 0.25***

6.25

1.25 ± 0.50***

68.8***

3.27 ± 0.29***

3.125

2.67 ± 0.58***

35.3**

3.34 ± 0.40***

1.563

2.75 ± 0.50**

31.7**

5.35 ± 0.48**

Placebo

–

4.00 ± 0.00

–

7.54 ± 0.61

Normal

–

0.00 ± 0.00

–

1.71 ± 0.14

  1. *p < 0.05, **p < 0.01, ***p < 0.001, the values were compared with placebo controls.
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