Figure 1
From: Astrocyte-derived adenosine is central to the hypnogenic effect of glucose
VLPO arterioles are glucose sensitive.
(a) Mean ± SEM vascular responses induced by the extracellular increase in glucose concentration from 1 to 5 mM in the VLPO core (in red; n = 7), as compared to the VLPO border (in blue; n = 4) and to the somatosensory cortex (S1) (in green; n = 6) in vessels preconstricted with U46619. (b) Photomicrograph of an arteriole dilating in response to the increase in glucose concentration in the VLPO core. (c) Box plots of the vascular response measured at 19–20 min after the glucose switch in the VLPO core, at its border and in the somatosensory cortex (S1). The median is plotted as the central black bar of the box, the upper and lower quartiles are the edges of the box and the whiskers show the extremes of the distribution. Sample sizes are indicated in parentheses. (d) Dose-response curve of the glucose effect. **P < 0.01, ***P < 0.001; Mann-Whitney U-test.
