Figure 6
From: Astrocyte-derived adenosine is central to the hypnogenic effect of glucose
A2AR blockade does not prevent the glucose sensitivity of VLPO NA (−) neurons.
(a) Box plots of NA (−) neurons recorded in ZM 241385 at 5 and 1 mM glucose. The median is plotted as the central red bar of the box, the upper and lower quartiles are the edges of the box and the whiskers show the extremes of the distribution. Sample sizes are indicated in parentheses. *P < 0.05; paired t-test. (b) Example of a firing frequency kinetic from a NA (−) neuron presented in (a). Note that 2 steps mark the return to the base-line level for the ZM 241385 first and for the glucose effect as previously reported21.
