Figure 3
From: Extracellular ATP mediates inflammatory responses in colitis via P2 × 7 receptor signaling
Blockade of ATP degradation exacerbates DSS-induced colitis.
After induction of DSS colitis, the mice with colitis were administrated with vehicle, POM1 (10 mg/kg, i.p), or/and ATP (1 mg dissolved in 0.1 mL PBS per mouse, enema) daily since day 3 to day 7. CD39 expression was examined by immunohistochemistry before and 7 days after induction of colitis (a), scale bars: 250 μm. At day 8, ATP levels in colon tissues were determined (n = 5) (b), body weight changes (c) and DAI (d) were recorded and histological scores were graded (e), respectively (n = 10). *p < 0.05; **p < 0.01.
