Figure 3
From: Systematic Analysis of Sex-Linked Molecular Alterations and Therapies in Cancer
Male-Female Connectivity Score Scatterplots.
Male-female distribution of connectivity scores of perturbagens (gene perturbations & drugs) in (A) LIHC, (B) LUAD and (C) LUSC. These three cancers returned the largest number of sex-specific (Type I or II) perturbagens. Scores were obtained by querying the LincsCloud connectivity map for perturbagens which are positively associated with the sensitivity signature and negatively associated with the resistance signature for each cancer within each sex. Black points are genetic constructs (overexpression or knockdown); orange points are small-molecule compounds. Blue points are the five Type I perturbagens with greatest magnitude sex difference in connectivity score, pink points are the five Type II perturbagens with greatest magnitude sex difference in score and violet points are the five Type III perturbagens with greatest sum of connectivity score. Green points indicate FDA-approved drugs.
