Table 4 Connectivity Scores and Permutation BH-values of Novel Predicted Type I, II and III Perturbagens.

From: Systematic Analysis of Sex-Linked Molecular Alterations and Therapies in Cancer

Perturbagen

Cancer

Male Score

Female Score

Predicted Type

BH-value

CDK1 knockdown

LIHC

74.26

−66.44

I

<0.0001

PTPN1 knockdown

LUSC

70.89

−86.40

I

<0.0001

SMAD3 knockdown

HNSC

−79.27

82.37

II

<0.0001

HSPA4 knockdown

HNSC

−80.84

78.58

II

<0.0001

Midostaurin

All

−71.30

89.33

II

<0.0001

Etoposide

LIHC

98.76

99.70

III

0.9575

Camptothecin

LIHC

98.97

99.25

III

0.9498

  1. The table summarizes several predictions for sex-dependent and sex-independent perturbagens. The BH-value quantifies the statistical significance of the male-female connectivity score difference, as computed by our permutation analyses (see Materials and Methods). “All” indicates that the perturbagen prediction was made on pan-cancer resistance and sensitivity signatures.
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