Figure 5 | Scientific Reports

Figure 5

From: Astragaloside IV inhibits microglia activation via glucocorticoid receptor mediated signaling pathway

Figure 5

RU486 abrogated the inhibitory effect of ASI on microglial activation in EAE mice.

(A) RU486 conteracted the inhibitory effect of ASI on clinical scores in EAE mice. (B) RU486 mitigated the inhibition of phosphorylation of Tau by ASI in spinal cords. (C–F) RU486 abolished the suppressive effect of ASI on gene expressions of CD11b, IL1β, TNFα and iNOS in EAE mice. One-way ANOVA with Dunnett’s multiple comparison test was used for the statistics. *p < 0.05, **p < 0.01, ***p < 0.001 vs EAE group, N = 7/group, mean ± S.E.M.

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