Figure 5 | Scientific Reports

Figure 5

From: Nutritional conditions regulate transcriptional activity of SF-1 by controlling sumoylation and ubiquitination

Figure 5

Model of the molecular mechanisms of SF-1 regulation by sumoylation and ubiquitination.

In fed conditions, SF-1 sumoylation is increased by activation of the insulin-PI3K signaling pathway and promotes SF-1-mediated transcriptional regulation. Conversely, sumoylation of SF-1 acts as a degradation signal under fasted conditions. Therefore, sumoylation promotes ubiquitin-dependent degradation of SF-1 and attenuates SF-1 transcriptional activity under fasted condition.

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