Figure 1

(A) Scheme for the PAHylation and peptide/micromolecule modifications on the Raman dye-coated Au-NPs: CV-coated Au-NPs were modified with PAH and FA for targeting the membrane; CVa-coated Au-NPs were modified with PAH and LHRH peptide for also targeting the membrane; MBA-coated Au-NPs were modified with PAH and NLS peptide for targeting the nucleus. (B–D) Representative Raman spectra of CV-coated AuNPs (B), CVa-coated AuNPs (C) and MBA-coated AuNPs (D) obtained from particle solution with an incident laser power of 3.0 mW and 1 s exposure time per spectrum.