Figure 5 | Scientific Reports

Figure 5

From: A CRISPR/Cas9 and Cre/Lox system-based express vaccine development strategy against re-emerging Pseudorabies virus

Figure 5

Protective effect of PRV-HNX TK−/gE− in mice.

(a) Two group of mice were subcutaneously injected with PRV HNX or PRV-HNX TK−/gE− and were monitored for survival rate for two weeks. Mice were vaccinated PRV-HNX TK−/gE− or DMEM and then challenged with PRV HNX (b), PRV Ea (c) and PRV-Becker-GFP (d) two weeks later. Survival rate were monitored for two weeks. (e) Fluorescence imaging of the brain stem section of the mice vaccinated PRV-HNX TK−/gE− or DMEM respectively and then challenged with PRV-Becker-GFP (five mice per group).

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