Figure 1 | Scientific Reports

Figure 1

From: Bispecific Antibody Affords Complete Post-Exposure Protection of Mice from Both Ebola (Zaire) and Sudan Viruses

Figure 1

Design of bispecific antibodies.

KZ52 is a human EBOV mAb and F4 and E10 are synthetic human scaffold SUDV mAbs. (a) The binding sites of KZ52 on EBOV GP (PDB ID: 3CSY) and 16F6, the murine parent of E10 and F4, on SUDV GP (PDB ID: 3S88) are similar and involve a structural epitope at the base of the prefusion trimer15,22. (b) Bis-mAbs described here consist of fusions between the KZ52 scFv (VH-VL topology) and the IgG of either F4 or E10. (c) Several fusion topologies were examined: heavy chain N-terminus (HCN), light chain N-terminus (LCN), heavy chain C-terminus (HCC) and light chain C-terminus (LCC).

Back to article page