Figure 3 | Scientific Reports

Figure 3

From: Bispecific Antibody Affords Complete Post-Exposure Protection of Mice from Both Ebola (Zaire) and Sudan Viruses

Figure 3

Virus neutralization.

(a) Single-point neutralization assay of all Bis-mAbs at 100 nM against VSV-GPEBOV or VSV-GPSUDV. KZ52, F4 and E10 were included as controls. In addition, equimolar mixtures of E10 + KZ52 and F4 + KZ52 at 130 nM (equivalent mass amounts to Bis-mAbs) were included for comparison. (b) Dose-dependent neutralization of VSV-GPEBOV and VSV-GPSUDV by scKZ52-F4 LCN, scKZ52-F4 HCC, scKZ52-E10 LCN and scKZ52-E10 HCC. Calculated IC50 values are listed next to each curve. (c) Neutralization of authentic viruses by PRNT assay, with IC50 values listed.

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