Figure 4

Animal challenge experiments.

Percent survival and median percent weight change for mouse-adapted EBOV (a) and SUDV (b) challenges with antibody treatment. Mice were treated with a single post-exposure dose (200 μg at 24 hours) for EBOV or two post-exposure doses (500 μg at days +1 and +4) for SUDV. Statistical p-values are listed against PBS and F4 controls for EBOV and against Z.6D8 control for SUDV (****p < 0.0001; **p < 0.01; *p < 0.05; p-values greater that 0.05 are listed numerically; na, not applicable). (c,d) Rechallenge of surviving mice from initial challenge cohorts, with no further antibody treatment.