Figure 1 | Scientific Reports

Figure 1

From: Direct Actions of Kisspeptins on GnRH Neurons Permit Attainment of Fertility but are Insufficient to Fully Preserve Gonadotropic Axis Activity

Figure 1

Female reproductive phenotype of the Gpr54−/−Tg rescued mouse.

Body and gonadal weights, as well as serum LH and FSH levels in adult WT, Gpr54−/−Tg rescued and Gpr54−/− null female mice are shown in panel (A). In addition, in panel (B), representative photographs of the ovaries of uteri of the three genotypes are presented. Finally, studies of the dynamics of estrous cyclicity are presented in panels (C,D); these included the assessment of the number of days per each stage of the estrous cycle over a period of 30-days and the average cycle length during this period in WT and rescued female mice. Note that Gpr54−/− null females did not display vaginal opening and, hence, no cytological analyses were conducted in this genotype. *P < 0.05 and **P < 0.01 vs. corresponding WT groups (Student t-tests or ANOVA followed by Student-Newman-Keuls multiple range test).

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