Figure 5 | Scientific Reports

Figure 5

From: Direct Actions of Kisspeptins on GnRH Neurons Permit Attainment of Fertility but are Insufficient to Fully Preserve Gonadotropic Axis Activity

Figure 5

Perturbed negative feedback in the Gpr54−/−Tg rescued female mouse.

Serum LH and FSH levels before and at different time-points after removal of gonadal feedback input by ovariectomy (OVX) were measured in adult WT, Gpr54−/−Tg rescued and Gpr54−/− null female mice. In panel (A), serum LH levels at basal conditions and 48-hour, 7-day, 21-day after OVX are shown; integral levels over the study-period, calculated as AUC by the trapezoidal rule, as presented in panel (B). Similar analyses of changes in FSH levels following OVX in the three genotypes are presented in panels (C,D). **P < 0.01 vs. corresponding basal (pre-GNX) levels; a, b P < 0.05 vs. corresponding WT groups (ANOVA followed by Student-Newman-Keuls multiple range test).

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