Figure 2 | Scientific Reports

Figure 2

From: Mutant p53 determines pancreatic cancer poor prognosis to pancreatectomy through upregulation of cavin-1 in patients with preoperative serum CA19-9 ≥ 1,000 U/mL

Figure 2

Expression of molecules in the cavins/caveolin-1 axis in pancreatic ductal adenocarcinoma (PDAC).

(A,B) Representative images of low and high cavin-1 expression in PDAC tissue. Cavin-1 was mainly located in the cytoplasm of neoplastic cells and scattered expression was also seen in the nuclei (×200 magnification). (C) The differentially expressed molecules in the cavins/caveolin-1 axis in the training cohort according to the CA19-9 categorization. Compared with patients with CA19-9 < 1,000 U/mL, the levels of cavin-1 and caveolin-1 were significantly higher in patients with CA19-9 ≥ 1,000 U/mL (*P < 0.01), whereas no statistical difference was found for cavin-2, -3 and -4. (D) Differential expression of cavin-1 and caveolin-1 in subgroups of patients with CA19-9 ≥ 1,000 U/mL. The level of cavin-1, rather than caveolin-1, was dramatically higher in patients with CA19-9 that did not decrease postresection, compared with patients whose CA19-9 did decrease postresection (*P = 0.017).

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