Table 2 Correlations between the overexpression of mutant p53 and cavin-1 expression with clinicopathological parameters in the training cohort.
Variables | p53 staining | Cavin-1 density | ||||
|---|---|---|---|---|---|---|
Mutant (n = 84) No. (%) | Non-mutant (n = 157) No. (%) | P value | Low (n = 161) No. (%) | High (n = 80) No. (%) | P value | |
Gender | 0.985 | 0.879 | ||||
Female | 32 (38) | 60 (38) | 62 (39) | 30 (38) | ||
Male | 52 (62) | 97 (62) | 99 (61) | 50 (62) | ||
Age, years | 0.150 | 0.676 | ||||
≤60 | 32 (38) | 75 (48) | 73 (45) | 34 (43) | ||
>60 | 52 (62) | 82 (52) | 88 (55) | 46 (57) | ||
Preoperative CA19-9, U/mL | <0.001 | <0.001 | ||||
<1000 | 26 (31) | 126 (80) | 123 (76) | 29 (36) | ||
≥1000 | 58 (69) | 31 (20) | 38 (24) | 51 (64) | ||
Tumor size, cm | 0.002 | 0.676 | ||||
≤2 | 26 (31) | 81 (52) | 73 (45) | 34 (43) | ||
>2 | 58 (69) | 76 (48) | 88 (55) | 46 (57) | ||
Tumor location | 0.242 | 0.966 | ||||
Head | 41 (49) | 89 (57) | 87 (54) | 43 (54) | ||
Body/tail | 43 (51) | 68 (43) | 74 (46) | 37 (46) | ||
Tumor differentiation | 0.104 | 0.154 | ||||
Low (Stage III–IV) | 52 (62) | 80 (51) | 83 (52) | 49 (61) | ||
High (Stage I–II) | 32 (38) | 77 (49) | 78 (48) | 31 (39) | ||
Lymph node involvement | 0.001 | 0.009 | ||||
No | 24 (29) | 80 (51) | 79 (49) | 25 (31) | ||
Yes | 60 (71) | 77 (49) | 82 (51) | 55 (69) | ||
Microvascular invasion | <0.001 | <0.001 | ||||
No | 38 (45) | 139 (88) | 140 (87) | 37 (46) | ||
Yes | 46 (55) | 18 (12) | 21 (13) | 43 (54) | ||
Perineural invasion | 0.024 | 0.030 | ||||
No | 21 (25) | 62 (40) | 63 (39) | 20 (25) | ||
Yes | 63 (75) | 95 (60) | 98 (61) | 60 (75) | ||
T factor (UICC) | 0.009 | 0.011 | ||||
T1/T2 | 21 (25) | 66 (42) | 67 (42) | 20 (25) | ||
T3 | 63 (75) | 91 (58) | 94 (58) | 60 (75) | ||
TNM stage (UICC) | 0.046 | 0.038 | ||||
IB | 7 (8) | 31 (20) | 32 (20) | 6 (8) | ||
IIA | 31 (37) | 43 (27) | 45 (28) | 29 (36) | ||
IIB | 46 (55) | 83 (53) | 84 (52) | 45 (56) | ||
Cavin-1 density | <0.001 | — | ||||
Low | 31 (37) | 130 (83) | — | — | ||
High | 53 (63) | 27 (17) | — | — | ||
